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Curcumin halts spread of breast cancer in mice - Early study shows spice stunts deadly spread to lungs (Full Article)

Category: Cancer/Oncology News
Article Date: 17 Oct 2005

Curcumin, the main ingredient of turmeric and the compound that gives curry its mustard-yellow color, inhibits metastasis to the lungs of mice with breast cancer, report researchers at The University of Texas M. D. Anderson Cancer Center.

The study, to be published in the Oct. 15 issue of the journal Clinical Cancer Research, reports that the spice appears to shut down a protein active in the spread of breast cancer to a major target for metastasis.

Though the study results are early, researchers found that the nontoxic natural substance not only repelled progression of the disease to the lungs, but also appeared to reverse the effects of paclitaxel (TaxolTM), a commonly prescribed chemotherapy for breast cancer that may trigger spread of the disease with use over a long period of time.

Because Taxol is so toxic, it activates a protein that produces an inflammatory response that induces metastasis. Curcumin suppresses this response, making it impossible for the cancer to spread. In fact, researchers found that adding curcumin to Taxol actually enhances its effect. Curcumin breaks down the dose, making the therapy less toxic and just as powerful while delivering the same level of efficacy.

"We are excited about the results of the study and the possible implications for taking the findings into the clinic in the next several years," says Bharat Aggarwal, Ph.D., professor of cancer medicine in M. D. Anderson's Department of Experimental Therapeutics. "At this time, advanced breast cancer is a difficult foe to fight with few proven treatments available after surgery, chemotherapy and radiation therapy."

Taxol is currently used as the front-line chemotherapeutic agent in breast cancers, but because the drug frequently induces drug resistance after prolonged use, it is not effective in treating metastatic breast cancer, says Aggarwal.

Researchers studied 60 mice with breast cancer, which were randomly assigned to one of four groups: control group, Taxol only, curcumin only and the combination of Taxol and curcumin. After the tumors grew to 10 mm (about the size of a pea), they were surgically removed, and the mice were fed a powdered curcumin diet.

Macroscopic lung metastasis, or metastasis that is visible to the naked eye, was seen in 96 percent of the mice in the control group. Treatment using Taxol alone only "modestly reduced" the incidence of metastases, while the group using curcumin alone and curcumin plus Taxol "significantly reduced" both the incidence and numbers of visible lung metastases.

Microscopic metastasis, or metastasis that is visible only when using a microscope, was found in the lungs of 28 percent of mice treated with the combination of curcumin and Taxol, and there was no macroscopic disease present. The micrometastases present consisted of only a few cells, suggesting that the combination inhibited the growth of breast cancer tumor cells that were in the lung before the tumors were removed.

In a previous study published in the Aug. 15 issue of the journal Cancer, M. D. Anderson researchers found that when the nuclear factor-kappa B (NF-kB) (a powerful protein known to promote the inflammatory response necessary to cause breast cancer to spread) is shut down, cancer strains are unable to grow and cells are pushed to commit suicide.

The mechanism in this curcumin study works the same way. Taxol activated the NF-kB in breast cancer cells, while curcumin stopped this activation by blocking the protein known as "IKK" that switched on the NF-kB, demonstrating how curcumin and Taxol work against one another. Taxol produced the inflammatory response, triggering metastasis, and curcumin suppressed it, causing cell death.

Extracted from the roots of the curcuma longa plant, curcumin is a member of the ginger family. While it is not used in conventional medicine, it is widely prescribed in Indian medicine as a potent remedy for liver disorders, rheumatism, diabetic wounds, runny nose, cough and sinusitis. Traditional Chinese medicine uses curcumin as a treatment for diseases associated with abdominal pain, and it is used in ancient Hindu medicine as a treatment for sprains and swelling.

According to the American Cancer Society, the chance of a woman having invasive breast cancer sometime during her life is one in eight. About 211,240 women in the United States will be diagnosed with invasive breast cancer in 2005, and approximately 40,410 women will die from the disease this year.

The study was funded by the United States Department of Defense. Co-authors include Shishir Shishodia, Ph.D.; Yasunari Takada, Ph.D.; Sanjeev Banerjee, Ph.D.; Robert A. Newman, Ph.D.; Carlos Bueso-Ramos, M.D., Ph.D.; and Janet E. Price, Ph.D.

Heather Sessions
hrsessions@mdanderson.org
University of Texas M. D.
Anderson Cancer Center
http://www.mdanderson.org

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Healthy eating, exercise key to keeping brain fit, say scientists (Full Article) full3

By Dominique Patton9/8/2005 - Regular exercise and a diet rich in antioxidants and omega-3s may help the elderly stave off memory loss, said Irish scientists yesterday.

Over the last decade, it has become clear that just as changes in diet and exercise will improve physical fitness, the 'ageing' brain also benefits from simple changes in environment and lifestyle.

And as people live longer, protecting against the decline in mental function is becoming increasingly important, Professor Ian Robertson, director of the Institute of Neuroscience at Trinity College Dublin, told those attending the British Association for the Advancement of Science meeting in Dublin.

"The biggest threat to being able to function well and properly is our brains," he told journalists.

"There is very strong evidence, particularly in the over-50s, that the degree to which you maintain your mental faculties depends on a handful of quite simple environmental factors," added Professor Robertson.

Aerobic fitness is one of the best ways of boosting activity and structure of brain cells, he said, citing a training programme that showed over 60s had an improved mental ability after only four months, while people who continued such a programme for three years avoided the drop in mental sharpness experienced by people not exercising.

Avoiding high stress levels and continuing a rich, social life are also important, as is healthy diet, said Professor Robertson, citing the role of antioxidants in protecting the brain from ageing.

A fellow Trinity professor, Marina Lynch, further emphasised the role of the diet, pointing to new research into fish oils.

A Scottish study published last year found that cognitive function at age 64 was better in a subgroup of persons who received a fish oil supplement compared with a subgroup which received no supplement.

"Studies have identified the anti-inflammatory properties as well as the restorative qualities of omega-3," she said.

Lynch said the biggest surprise of the latest discovery was that omega-3 appeared not only to replace anti-inflammatories that dwindle with age but also to stem a corresponding rise in chemicals that cause the cell inflammation in the first place.

"These effects seem to cobble together to restore the ability of people to maintain memory as they grow older," added Professor Lynch.

The proportion of the population aged 65 and over has been increasing rapidly in recent decades. In 2000 16 per cent of the population was over 65; it is estimated that this will increase to 24.89 per cent by 2050, said the researcher.

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